Click here to access PB0175 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0175 P01009 Alpha-1-antitrypsin SERPINA1 A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT, nNIF, serpin family A member 1 Homo_sapiens Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.

DomainsGene Ontology
PF00079 (Serpin)
GO:0002020 (enables) protease binding
GO:0004867 (enables) serine-type endopeptidase inhibitor activity
GO:0005515 (enables) protein binding
GO:0030414 (enables) peptidase inhibitor activity
GO:0042802 (enables) identical protein binding
GO:0006953 (involved in) acute-phase response
GO:0007596 (involved in) blood coagulation
GO:0007599 (involved in) hemostasis
GO:0010466 (involved in) negative regulation of peptidase activity
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005783 (located in) endoplasmic reticulum
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005794 (located in) Golgi apparatus
GO:0030134 (located in) COPII-coated ER to Golgi transport vesicle
GO:0031093 (located in) platelet alpha granule lumen
GO:0033116 (located in) endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0043231 (located in) intracellular membrane-bounded organelle
GO:0070062 (located in) extracellular exosome
GO:1904813 (located in) ficolin-1-rich granule lumen
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)