PB0174
DATABASE


Click here to access PB0174 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0174 P07477 Trypsin-1 PRSS1 TRP1, TRY1, TRY4, TRYP1, serine protease 1 Homo_sapiens Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.

DomainsGene Ontology
PF00089 (Trypsin)
GO:0004252 (enables) serine-type endopeptidase activity
GO:0008233 (enables) peptidase activity
GO:0008236 (enables) serine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0046872 (enables) metal ion binding
GO:0006508 (involved in) proteolysis
GO:0007586 (involved in) digestion
GO:0022617 (involved in) extracellular matrix disassembly
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0072562 (located in) blood microparticle
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences


Created by Puigbo and Nakamura @ University of Turku (2022)