Click here to access PB0173 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0173 P13497 Bone morphogenetic protein 1 BMP1 OI13, PCOLC, PCP, PCP2, TLD Homo_sapiens Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation (PubMed:32636307).

DomainsGene Ontology
PF00431 (5_CUB)
PF01400 (Astacin)
PF07645 (EGF_CA)
GO:0061036 (acts upstream of or within) positive regulation of cartilage development
GO:0004222 (enables) metalloendopeptidase activity
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005125 (enables) cytokine activity
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008083 (enables) growth factor activity
GO:0008233 (enables) peptidase activity
GO:0008237 (enables) metallopeptidase activity
GO:0008270 (enables) zinc ion binding
GO:0016787 (enables) hydrolase activity
GO:0042802 (enables) identical protein binding
GO:0046872 (enables) metal ion binding
GO:0001501 (involved in) skeletal system development
GO:0001502 (involved in) cartilage condensation
GO:0001503 (involved in) ossification
GO:0006508 (involved in) proteolysis
GO:0007165 (involved in) signal transduction
GO:0007275 (involved in) multicellular organism development
GO:0009953 (involved in) dorsal/ventral pattern formation
GO:0016485 (involved in) protein processing
GO:0030154 (involved in) cell differentiation
GO:0030199 (involved in) collagen fibril organization
GO:0051216 (involved in) cartilage development
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005794 (located in) Golgi apparatus
GO:0031982 (located in) vesicle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)