Click here to access PB0171 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0171 P83110 Serine protease HTRA3 HTRA3 Prsp, Tasp, HtrA serine peptidase 3 Homo_sapiens May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724).

DomainsGene Ontology
PF00219 (IGFBP)
PF07648 (Kazal_2)
PF17820 (PDZ_6)
GO:0004175 (enables) endopeptidase activity
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005515 (enables) protein binding
GO:0008233 (enables) peptidase activity
GO:0008236 (enables) serine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0042802 (enables) identical protein binding
GO:0006508 (involved in) proteolysis
GO:0030512 (involved in) negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 (involved in) negative regulation of BMP signaling pathway
GO:0005576 (located in) extracellular region

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)