Click here to access PB0168 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0168 O75094 Slit homolog 3 protein SLIT3 MEGF5, SLIL2, SLIT1, Slit-3, slit2 Homo_sapiens May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.

DomainsGene Ontology
PF00008 (6_EGF)
PF01462 (3_LRRNT)
PF01463 (4_LRRCT)
PF02210 (Laminin_G_2)
PF12661 (hEGF)
PF13855 (5_LRR_8)
GO:0005509 (enables) calcium ion binding
GO:0008201 (enables) heparin binding
GO:0048495 (enables) Roundabout binding
GO:0003180 (involved in) aortic valve morphogenesis
GO:0003181 (involved in) atrioventricular valve morphogenesis
GO:0007399 (involved in) nervous system development
GO:0007411 (involved in) axon guidance
GO:0008285 (involved in) negative regulation of cell population proliferation
GO:0009887 (involved in) animal organ morphogenesis
GO:0010629 (involved in) negative regulation of gene expression
GO:0030154 (involved in) cell differentiation
GO:0030308 (involved in) negative regulation of cell growth
GO:0032870 (involved in) cellular response to hormone stimulus
GO:0035385 (involved in) Roundabout signaling pathway
GO:0048846 (involved in) axon extension involved in axon guidance
GO:0050919 (involved in) negative chemotaxis
GO:0051414 (involved in) response to cortisol
GO:0060412 (involved in) ventricular septum morphogenesis
GO:0061364 (involved in) apoptotic process involved in luteolysis
GO:0070100 (involved in) negative regulation of chemokine-mediated signaling pathway
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005739 (located in) mitochondrion

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)