Click here to access PB0167 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0167 Q66K79 Carboxypeptidase Z CPZ Homo_sapiens Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.

DomainsGene Ontology
PF00246 (Peptidase_M14)
PF01392 (Fz)
GO:0004180 (enables) carboxypeptidase activity
GO:0004181 (enables) metallocarboxypeptidase activity
GO:0008233 (enables) peptidase activity
GO:0008237 (enables) metallopeptidase activity
GO:0008270 (enables) zinc ion binding
GO:0016787 (enables) hydrolase activity
GO:0046872 (enables) metal ion binding
GO:0006508 (involved in) proteolysis
GO:0006518 (involved in) peptide metabolic process
GO:0016055 (involved in) Wnt signaling pathway
GO:0016485 (involved in) protein processing
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)