Click here to access PB0166 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0166 O94907 Dickkopf-related protein 1 DKK1 DKK-1, SK, dickkopf WNT signaling pathway inhibitor 1 Homo_sapiens Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).

DomainsGene Ontology
PF04706 (Dickkopf_N)
GO:0005515 (enables) protein binding
GO:0008083 (enables) growth factor activity
GO:0039706 (enables) co-receptor binding
GO:0048019 (enables) receptor antagonist activity
GO:0050750 (enables) low-density lipoprotein particle receptor binding
GO:0000122 (involved in) negative regulation of transcription by RNA polymerase II
GO:0000904 (involved in) cell morphogenesis involved in differentiation
GO:0001706 (involved in) endoderm formation
GO:0001707 (involved in) mesoderm formation
GO:0001942 (involved in) hair follicle development
GO:0002090 (involved in) regulation of receptor internalization
GO:0007492 (involved in) endoderm development
GO:0007611 (involved in) learning or memory
GO:0010628 (involved in) positive regulation of gene expression
GO:0010942 (involved in) positive regulation of cell death
GO:0010977 (involved in) negative regulation of neuron projection development
GO:0016055 (involved in) Wnt signaling pathway
GO:0030111 (involved in) regulation of Wnt signaling pathway
GO:0030178 (involved in) negative regulation of Wnt signaling pathway
GO:0030279 (involved in) negative regulation of ossification
GO:0030326 (involved in) embryonic limb morphogenesis
GO:0030514 (involved in) negative regulation of BMP signaling pathway
GO:0030900 (involved in) forebrain development
GO:0032091 (involved in) negative regulation of protein binding
GO:0032526 (involved in) response to retinoic acid
GO:0033137 (involved in) negative regulation of peptidyl-serine phosphorylation
GO:0042662 (involved in) negative regulation of mesodermal cell fate specification
GO:0042663 (involved in) regulation of endodermal cell fate specification
GO:0043066 (involved in) negative regulation of apoptotic process
GO:0043507 (involved in) positive regulation of JUN kinase activity
GO:0045813 (involved in) positive regulation of Wnt signaling pathway, calcium modulating pathway
GO:0050807 (involved in) regulation of synapse organization
GO:0051966 (involved in) regulation of synaptic transmission, glutamatergic
GO:0060173 (involved in) limb development
GO:0060323 (involved in) head morphogenesis
GO:0060325 (involved in) face morphogenesis
GO:0060394 (involved in) negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0061743 (involved in) motor learning
GO:0090082 (involved in) positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway
GO:0090244 (involved in) Wnt signaling pathway involved in somitogenesis
GO:0090647 (involved in) modulation of age-related behavioral decline
GO:0098883 (involved in) synapse pruning
GO:1901216 (involved in) positive regulation of neuron death
GO:1901296 (involved in) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment
GO:1902949 (involved in) positive regulation of tau-protein kinase activity
GO:1904338 (involved in) regulation of dopaminergic neuron differentiation
GO:1904723 (involved in) negative regulation of Wnt-Frizzled-LRP5/6 complex assembly
GO:1904958 (involved in) positive regulation of midbrain dopaminergic neuron differentiation
GO:1905607 (involved in) negative regulation of presynapse assembly
GO:2000096 (involved in) positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000272 (involved in) negative regulation of signaling receptor activity
GO:2000726 (involved in) negative regulation of cardiac muscle cell differentiation
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005886 (located in) plasma membrane
GO:0031901 (located in) early endosome membrane

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)