Click here to access PB0165 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0165 P08697 Alpha-2-antiplasmin SERPINF2 A2AP, AAP, ALPHA-2-PI, API, PLI, alpha2AP, serpin family F member 2 Homo_sapiens Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin.

DomainsGene Ontology
PF00079 (Serpin)
GO:0002020 (enables) protease binding
GO:0004866 (enables) endopeptidase inhibitor activity
GO:0004867 (enables) serine-type endopeptidase inhibitor activity
GO:0005515 (enables) protein binding
GO:0030414 (enables) peptidase inhibitor activity
GO:0042803 (enables) protein homodimerization activity
GO:0002034 (involved in) maintenance of blood vessel diameter homeostasis by renin-angiotensin
GO:0006953 (involved in) acute-phase response
GO:0010466 (involved in) negative regulation of peptidase activity
GO:0010757 (involved in) negative regulation of plasminogen activation
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0030199 (involved in) collagen fibril organization
GO:0032967 (involved in) positive regulation of collagen biosynthetic process
GO:0042730 (involved in) fibrinolysis
GO:0045597 (involved in) positive regulation of cell differentiation
GO:0045944 (involved in) positive regulation of transcription by RNA polymerase II
GO:0046330 (involved in) positive regulation of JNK cascade
GO:0048514 (involved in) blood vessel morphogenesis
GO:0048661 (involved in) positive regulation of smooth muscle cell proliferation
GO:0051496 (involved in) positive regulation of stress fiber assembly
GO:0051918 (involved in) negative regulation of fibrinolysis
GO:0070374 (involved in) positive regulation of ERK1 and ERK2 cascade
GO:0071636 (involved in) positive regulation of transforming growth factor beta production
GO:2000049 (involved in) positive regulation of cell-cell adhesion mediated by cadherin
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0009986 (located in) cell surface
GO:0031093 (located in) platelet alpha granule lumen
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle
GO:0005577 (part of) fibrinogen complex
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)