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PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0162 P05156 Complement factor I CFI AHUS3, ARMD13, C3BINA, C3b-INA, FI, IF, KAF Homo_sapiens The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization (PubMed:28671664).

DomainsGene Ontology
PF00057 (2_Ldl_recept_a)
PF00089 (Trypsin)
PF00530 (SRCR)
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005044 (enables) scavenger receptor activity
GO:0005515 (enables) protein binding
GO:0008233 (enables) peptidase activity
GO:0008236 (enables) serine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0046872 (enables) metal ion binding
GO:0002376 (involved in) immune system process
GO:0006508 (involved in) proteolysis
GO:0006897 (involved in) endocytosis
GO:0006958 (involved in) complement activation, classical pathway
GO:0045087 (involved in) innate immune response
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0016020 (located in) membrane
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)