Click here to access PB0161 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0161 P21333 Filamin-A FLNA ABP-280, ABPX, CSBS, CVD1, FGS2, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD Homo_sapiens During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons.

DomainsGene Ontology
PF00307 (CH)
PF00630 (23_Filamin)
GO:0090307 (acts upstream of or within) mitotic spindle assembly
GO:0001664 (enables) G protein-coupled receptor binding
GO:0003723 (enables) RNA binding
GO:0003779 (enables) actin binding
GO:0005080 (enables) protein kinase C binding
GO:0005515 (enables) protein binding
GO:0015459 (enables) potassium channel regulator activity
GO:0019900 (enables) kinase binding
GO:0031267 (enables) small GTPase binding
GO:0034988 (enables) Fc-gamma receptor I complex binding
GO:0042803 (enables) protein homodimerization activity
GO:0044325 (enables) transmembrane transporter binding
GO:0045296 (enables) cadherin binding
GO:0051015 (enables) actin filament binding
GO:0051020 (enables) GTPase binding
GO:0140297 (enables) DNA-binding transcription factor binding
GO:0001525 (involved in) angiogenesis
GO:0001837 (involved in) epithelial to mesenchymal transition
GO:0001974 (involved in) blood vessel remodeling
GO:0003007 (involved in) heart morphogenesis
GO:0007195 (involved in) adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007597 (involved in) blood coagulation, intrinsic pathway
GO:0010572 (involved in) positive regulation of platelet activation
GO:0010977 (involved in) negative regulation of neuron projection development
GO:0016479 (involved in) negative regulation of transcription by RNA polymerase I
GO:0030030 (involved in) cell projection organization
GO:0030036 (involved in) actin cytoskeleton organization
GO:0030334 (involved in) regulation of cell migration
GO:0031532 (involved in) actin cytoskeleton reorganization
GO:0032231 (involved in) regulation of actin filament bundle assembly
GO:0034394 (involved in) protein localization to cell surface
GO:0035855 (involved in) megakaryocyte development
GO:0042177 (involved in) negative regulation of protein catabolic process
GO:0042307 (involved in) positive regulation of protein import into nucleus
GO:0043066 (involved in) negative regulation of apoptotic process
GO:0043113 (involved in) receptor clustering
GO:0043123 (involved in) positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043433 (involved in) negative regulation of DNA-binding transcription factor activity
GO:0044319 (involved in) wound healing, spreading of cells
GO:0045022 (involved in) early endosome to late endosome transport
GO:0045184 (involved in) establishment of protein localization
GO:0045216 (involved in) cell-cell junction organization
GO:0048680 (involved in) positive regulation of axon regeneration
GO:0050808 (involved in) synapse organization
GO:0050821 (involved in) protein stabilization
GO:0051209 (involved in) release of sequestered calcium ion into cytosol
GO:0051220 (involved in) cytoplasmic sequestering of protein
GO:0051764 (involved in) actin crosslink formation
GO:0060271 (involved in) cilium assembly
GO:0070527 (involved in) platelet aggregation
GO:0071526 (involved in) semaphorin-plexin signaling pathway
GO:0072659 (involved in) protein localization to plasma membrane
GO:0090042 (involved in) tubulin deacetylation
GO:1900026 (involved in) positive regulation of substrate adhesion-dependent cell spreading
GO:1901381 (involved in) positive regulation of potassium ion transmembrane transport
GO:1905000 (involved in) regulation of membrane repolarization during atrial cardiac muscle cell action potential
GO:1905031 (involved in) regulation of membrane repolarization during cardiac muscle cell action potential
GO:2001046 (involved in) positive regulation of integrin-mediated signaling pathway
GO:0005576 (located in) extracellular region
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm
GO:0005802 (located in) trans-Golgi network
GO:0005829 (located in) cytosol
GO:0005856 (located in) cytoskeleton
GO:0005886 (located in) plasma membrane
GO:0005903 (located in) brush border
GO:0005911 (located in) cell-cell junction
GO:0005925 (located in) focal adhesion
GO:0005938 (located in) cell cortex
GO:0015629 (located in) actin cytoskeleton
GO:0016020 (located in) membrane
GO:0030018 (located in) Z disc
GO:0030426 (located in) growth cone
GO:0032432 (located in) actin filament bundle
GO:0042995 (located in) cell projection
GO:0043204 (located in) perikaryon
GO:0044295 (located in) axonal growth cone
GO:0070062 (located in) extracellular exosome
GO:1990779 (located in) glycoprotein Ib-IX-V complex
GO:0005730 (part of) nucleolus
GO:0031523 (part of) Myb complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)