PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0161 | P21333 | Filamin-A | FLNA | ABP-280, ABPX, CSBS, CVD1, FGS2, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD | Homo_sapiens | During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons. |
Domains | Gene Ontology |
PF00307 (CH) PF00630 (23_Filamin) |
GO:0090307 (acts upstream of or within) mitotic spindle assembly
GO:0001664 (enables) G protein-coupled receptor binding GO:0003723 (enables) RNA binding GO:0003779 (enables) actin binding GO:0005080 (enables) protein kinase C binding GO:0005515 (enables) protein binding GO:0015459 (enables) potassium channel regulator activity GO:0019900 (enables) kinase binding GO:0031267 (enables) small GTPase binding GO:0034988 (enables) Fc-gamma receptor I complex binding GO:0042803 (enables) protein homodimerization activity GO:0044325 (enables) transmembrane transporter binding GO:0045296 (enables) cadherin binding GO:0051015 (enables) actin filament binding GO:0051020 (enables) GTPase binding GO:0140297 (enables) DNA-binding transcription factor binding GO:0001525 (involved in) angiogenesis GO:0001837 (involved in) epithelial to mesenchymal transition GO:0001974 (involved in) blood vessel remodeling GO:0003007 (involved in) heart morphogenesis GO:0007195 (involved in) adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007597 (involved in) blood coagulation, intrinsic pathway GO:0010572 (involved in) positive regulation of platelet activation GO:0010977 (involved in) negative regulation of neuron projection development GO:0016479 (involved in) negative regulation of transcription by RNA polymerase I GO:0030030 (involved in) cell projection organization GO:0030036 (involved in) actin cytoskeleton organization GO:0030334 (involved in) regulation of cell migration GO:0031532 (involved in) actin cytoskeleton reorganization GO:0032231 (involved in) regulation of actin filament bundle assembly GO:0034394 (involved in) protein localization to cell surface GO:0035855 (involved in) megakaryocyte development GO:0042177 (involved in) negative regulation of protein catabolic process GO:0042307 (involved in) positive regulation of protein import into nucleus GO:0043066 (involved in) negative regulation of apoptotic process GO:0043113 (involved in) receptor clustering GO:0043123 (involved in) positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043433 (involved in) negative regulation of DNA-binding transcription factor activity GO:0044319 (involved in) wound healing, spreading of cells GO:0045022 (involved in) early endosome to late endosome transport GO:0045184 (involved in) establishment of protein localization GO:0045216 (involved in) cell-cell junction organization GO:0048680 (involved in) positive regulation of axon regeneration GO:0050808 (involved in) synapse organization GO:0050821 (involved in) protein stabilization GO:0051209 (involved in) release of sequestered calcium ion into cytosol GO:0051220 (involved in) cytoplasmic sequestering of protein GO:0051764 (involved in) actin crosslink formation GO:0060271 (involved in) cilium assembly GO:0070527 (involved in) platelet aggregation GO:0071526 (involved in) semaphorin-plexin signaling pathway GO:0072659 (involved in) protein localization to plasma membrane GO:0090042 (involved in) tubulin deacetylation GO:1900026 (involved in) positive regulation of substrate adhesion-dependent cell spreading GO:1901381 (involved in) positive regulation of potassium ion transmembrane transport GO:1905000 (involved in) regulation of membrane repolarization during atrial cardiac muscle cell action potential GO:1905031 (involved in) regulation of membrane repolarization during cardiac muscle cell action potential GO:2001046 (involved in) positive regulation of integrin-mediated signaling pathway GO:0005576 (located in) extracellular region GO:0005634 (located in) nucleus GO:0005737 (located in) cytoplasm GO:0005802 (located in) trans-Golgi network GO:0005829 (located in) cytosol GO:0005856 (located in) cytoskeleton GO:0005886 (located in) plasma membrane GO:0005903 (located in) brush border GO:0005911 (located in) cell-cell junction GO:0005925 (located in) focal adhesion GO:0005938 (located in) cell cortex GO:0015629 (located in) actin cytoskeleton GO:0016020 (located in) membrane GO:0030018 (located in) Z disc GO:0030426 (located in) growth cone GO:0032432 (located in) actin filament bundle GO:0042995 (located in) cell projection GO:0043204 (located in) perikaryon GO:0044295 (located in) axonal growth cone GO:0070062 (located in) extracellular exosome GO:1990779 (located in) glycoprotein Ib-IX-V complex GO:0005730 (part of) nucleolus GO:0031523 (part of) Myb complex |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |