Click here to access PB0160 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0160 P61812 Transforming growth factor beta-2 proprotein TGFB2 G-TSF, LDS4, TGF-beta2 Homo_sapiens Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.

DomainsGene Ontology
PF00019 (TGF_beta)
PF00688 (TGFb_propeptide)
GO:0001540 (enables) amyloid-beta binding
GO:0005102 (enables) signaling receptor binding
GO:0005114 (enables) type II transforming growth factor beta receptor binding
GO:0005125 (enables) cytokine activity
GO:0005160 (enables) transforming growth factor beta receptor binding
GO:0005515 (enables) protein binding
GO:0008083 (enables) growth factor activity
GO:0034714 (enables) type III transforming growth factor beta receptor binding
GO:0042803 (enables) protein homodimerization activity
GO:0000902 (involved in) cell morphogenesis
GO:0001501 (involved in) skeletal system development
GO:0001654 (involved in) eye development
GO:0001666 (involved in) response to hypoxia
GO:0001822 (involved in) kidney development
GO:0001837 (involved in) epithelial to mesenchymal transition
GO:0001843 (involved in) neural tube closure
GO:0001942 (involved in) hair follicle development
GO:0003007 (involved in) heart morphogenesis
GO:0003148 (involved in) outflow tract septum morphogenesis
GO:0003149 (involved in) membranous septum morphogenesis
GO:0003179 (involved in) heart valve morphogenesis
GO:0003181 (involved in) atrioventricular valve morphogenesis
GO:0003184 (involved in) pulmonary valve morphogenesis
GO:0003203 (involved in) endocardial cushion morphogenesis
GO:0003215 (involved in) cardiac right ventricle morphogenesis
GO:0003222 (involved in) ventricular trabecula myocardium morphogenesis
GO:0003274 (involved in) endocardial cushion fusion
GO:0003289 (involved in) atrial septum primum morphogenesis
GO:0003407 (involved in) neural retina development
GO:0006468 (involved in) protein phosphorylation
GO:0007179 (involved in) transforming growth factor beta receptor signaling pathway
GO:0007435 (involved in) salivary gland morphogenesis
GO:0007507 (involved in) heart development
GO:0008219 (involved in) cell death
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0008285 (involved in) negative regulation of cell population proliferation
GO:0008347 (involved in) glial cell migration
GO:0008584 (involved in) male gonad development
GO:0009410 (involved in) response to xenobiotic stimulus
GO:0009611 (involved in) response to wounding
GO:0009792 (involved in) embryo development ending in birth or egg hatching
GO:0010002 (involved in) cardioblast differentiation
GO:0010629 (involved in) negative regulation of gene expression
GO:0010634 (involved in) positive regulation of epithelial cell migration
GO:0010693 (involved in) negative regulation of alkaline phosphatase activity
GO:0010718 (involved in) positive regulation of epithelial to mesenchymal transition
GO:0010862 (involved in) positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936 (involved in) negative regulation of macrophage cytokine production
GO:0014068 (involved in) positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477 (involved in) cell migration
GO:0016525 (involved in) negative regulation of angiogenesis
GO:0030097 (involved in) hemopoiesis
GO:0030199 (involved in) collagen fibril organization
GO:0030307 (involved in) positive regulation of cell growth
GO:0030308 (involved in) negative regulation of cell growth
GO:0030326 (involved in) embryonic limb morphogenesis
GO:0030509 (involved in) BMP signaling pathway
GO:0030593 (involved in) neutrophil chemotaxis
GO:0031069 (involved in) hair follicle morphogenesis
GO:0032147 (involved in) activation of protein kinase activity
GO:0032570 (involved in) response to progesterone
GO:0032874 (involved in) positive regulation of stress-activated MAPK cascade
GO:0032909 (involved in) regulation of transforming growth factor beta2 production
GO:0033630 (involved in) positive regulation of cell adhesion mediated by integrin
GO:0035910 (involved in) ascending aorta morphogenesis
GO:0042060 (involved in) wound healing
GO:0042127 (involved in) regulation of cell population proliferation
GO:0042416 (involved in) dopamine biosynthetic process
GO:0042476 (involved in) odontogenesis
GO:0042704 (involved in) uterine wall breakdown
GO:0043525 (involved in) positive regulation of neuron apoptotic process
GO:0045216 (involved in) cell-cell junction organization
GO:0045726 (involved in) positive regulation of integrin biosynthetic process
GO:0045747 (involved in) positive regulation of Notch signaling pathway
GO:0045778 (involved in) positive regulation of ossification
GO:0045787 (involved in) positive regulation of cell cycle
GO:0045823 (involved in) positive regulation of heart contraction
GO:0046580 (involved in) negative regulation of Ras protein signal transduction
GO:0048103 (involved in) somatic stem cell division
GO:0048566 (involved in) embryonic digestive tract development
GO:0048666 (involved in) neuron development
GO:0048699 (involved in) generation of neurons
GO:0048839 (involved in) inner ear development
GO:0050680 (involved in) negative regulation of epithelial cell proliferation
GO:0050714 (involved in) positive regulation of protein secretion
GO:0050778 (involved in) positive regulation of immune response
GO:0051781 (involved in) positive regulation of cell division
GO:0051794 (involved in) regulation of timing of catagen
GO:0051795 (involved in) positive regulation of timing of catagen
GO:0051891 (involved in) positive regulation of cardioblast differentiation
GO:0060038 (involved in) cardiac muscle cell proliferation
GO:0060065 (involved in) uterus development
GO:0060317 (involved in) cardiac epithelial to mesenchymal transition
GO:0060389 (involved in) pathway-restricted SMAD protein phosphorylation
GO:0060395 (involved in) SMAD protein signal transduction
GO:0060412 (involved in) ventricular septum morphogenesis
GO:0060413 (involved in) atrial septum morphogenesis
GO:0061626 (involved in) pharyngeal arch artery morphogenesis
GO:0062009 (involved in) secondary palate development
GO:0097191 (involved in) extrinsic apoptotic signaling pathway
GO:1902256 (involved in) regulation of apoptotic process involved in outflow tract morphogenesis
GO:1902895 (involved in) positive regulation of miRNA transcription
GO:1903701 (involved in) substantia propria of cornea development
GO:1904888 (involved in) cranial skeletal system development
GO:1905006 (involved in) negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905007 (involved in) positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0030424 (located in) axon
GO:0031093 (located in) platelet alpha granule lumen
GO:0043025 (located in) neuronal cell body
GO:0062023 (located in) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)