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| PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
| PB0153 | Q01955 | Collagen alpha-3(IV) chain | COL4A3 | ATS2, ATS3, collagen type IV alpha 3 chain | Homo_sapiens | Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms |
| Domains | Gene Ontology |
| PF01391 (21_Collagen) PF01413 (2_C4) |
GO:0005178 (enables) integrin binding
GO:0005198 (enables) structural molecule activity GO:0005201 (enables) extracellular matrix structural constituent GO:0005515 (enables) protein binding GO:0008191 (enables) metalloendopeptidase inhibitor activity GO:0030020 (enables) extracellular matrix structural constituent conferring tensile strength GO:0006919 (involved in) activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007155 (involved in) cell adhesion GO:0007166 (involved in) cell surface receptor signaling pathway GO:0007605 (involved in) sensory perception of sound GO:0008015 (involved in) blood circulation GO:0008285 (involved in) negative regulation of cell population proliferation GO:0009749 (involved in) response to glucose GO:0010951 (involved in) negative regulation of endopeptidase activity GO:0016525 (involved in) negative regulation of angiogenesis GO:0030198 (involved in) extracellular matrix organization GO:0032836 (involved in) glomerular basement membrane development GO:0038063 (involved in) collagen-activated tyrosine kinase receptor signaling pathway GO:0072577 (involved in) endothelial cell apoptotic process GO:1905563 (involved in) negative regulation of vascular endothelial cell proliferation GO:0005615 (is active in) extracellular space GO:0031012 (is active in) extracellular matrix GO:0005576 (located in) extracellular region GO:0005604 (located in) basement membrane GO:0005783 (located in) endoplasmic reticulum GO:0005788 (located in) endoplasmic reticulum lumen GO:0043231 (located in) intracellular membrane-bounded organelle GO:0005581 (part of) collagen trimer GO:0005587 (part of) collagen type IV trimer GO:0062023 (part of) collagen-containing extracellular matrix |
| External Links | Description |
| Intact | Open source database system and analysis tools for molecular interaction data. |
| Protein Atlas | An open access resource for human proteins |
| InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |