Click here to access PB0153 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0153 Q01955 Collagen alpha-3(IV) chain COL4A3 ATS2, ATS3, collagen type IV alpha 3 chain Homo_sapiens Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms

DomainsGene Ontology
PF01391 (21_Collagen)
PF01413 (2_C4)
GO:0005178 (enables) integrin binding
GO:0005198 (enables) structural molecule activity
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0008191 (enables) metalloendopeptidase inhibitor activity
GO:0030020 (enables) extracellular matrix structural constituent conferring tensile strength
GO:0006919 (involved in) activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007155 (involved in) cell adhesion
GO:0007166 (involved in) cell surface receptor signaling pathway
GO:0007605 (involved in) sensory perception of sound
GO:0008015 (involved in) blood circulation
GO:0008285 (involved in) negative regulation of cell population proliferation
GO:0009749 (involved in) response to glucose
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0016525 (involved in) negative regulation of angiogenesis
GO:0030198 (involved in) extracellular matrix organization
GO:0032836 (involved in) glomerular basement membrane development
GO:0038063 (involved in) collagen-activated tyrosine kinase receptor signaling pathway
GO:0072577 (involved in) endothelial cell apoptotic process
GO:1905563 (involved in) negative regulation of vascular endothelial cell proliferation
GO:0005615 (is active in) extracellular space
GO:0031012 (is active in) extracellular matrix
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005783 (located in) endoplasmic reticulum
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0043231 (located in) intracellular membrane-bounded organelle
GO:0005581 (part of) collagen trimer
GO:0005587 (part of) collagen type IV trimer
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)