Click here to access PB0152 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0152 P98160 Basement membrane-specific heparan sulfate proteoglycan core protein HSPG2 HSPG, PLC, PRCAN, SJA, SJS, SJS1, heparan sulfate proteoglycan 2 Homo_sapiens The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.

DomainsGene Ontology
PF00008 (2_EGF)
PF00052 (3_Laminin_B)
PF00053 (9_Laminin_EGF)
PF00054 (3_Laminin_G_1)
PF00057 (4_Ldl_recept_a)
PF07679 (9_I-set)
PF13895 (Ig_2)
GO:0001540 (enables) amyloid-beta binding
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008022 (enables) protein C-terminus binding
GO:0030021 (enables) extracellular matrix structural constituent conferring compression resistance
GO:0046872 (enables) metal ion binding
GO:0050750 (enables) low-density lipoprotein particle receptor binding
GO:0001525 (involved in) angiogenesis
GO:0006629 (involved in) lipid metabolic process
GO:0006898 (involved in) receptor-mediated endocytosis
GO:0006954 (involved in) inflammatory response
GO:0007420 (involved in) brain development
GO:0009887 (involved in) animal organ morphogenesis
GO:0009888 (involved in) tissue development
GO:0016525 (involved in) negative regulation of angiogenesis
GO:0030154 (involved in) cell differentiation
GO:0072359 (involved in) circulatory system development
GO:0005604 (is active in) basement membrane
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005796 (located in) Golgi lumen
GO:0005886 (located in) plasma membrane
GO:0005925 (located in) focal adhesion
GO:0043202 (located in) lysosomal lumen
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0098797 (part of) plasma membrane protein complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)