Click here to access PB0147 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0147 P08572 Collagen alpha-2(IV) chain COL4A2 BSVD2, ICH, POREN2, collagen type IV alpha 2 chain Homo_sapiens Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.

DomainsGene Ontology
PF01391 (17_Collagen)
PF01413 (2_C4)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0030020 (enables) extracellular matrix structural constituent conferring tensile strength
GO:0001525 (involved in) angiogenesis
GO:0006351 (involved in) transcription, DNA-templated
GO:0007568 (involved in) aging
GO:0014823 (involved in) response to activity
GO:0016525 (involved in) negative regulation of angiogenesis
GO:0030198 (involved in) extracellular matrix organization
GO:0035987 (involved in) endodermal cell differentiation
GO:0038063 (involved in) collagen-activated tyrosine kinase receptor signaling pathway
GO:0071560 (involved in) cellular response to transforming growth factor beta stimulus
GO:0005615 (is active in) extracellular space
GO:0031012 (is active in) extracellular matrix
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0005581 (part of) collagen trimer
GO:0005587 (part of) collagen type IV trimer

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)