Click here to access PB0146 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0146 P35443 Thrombospondin-4 THBS4 TSP-4, TSP4 Homo_sapiens Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity).

DomainsGene Ontology
PF02412 (6_TSP_3)
PF05735 (TSP_C)
PF07645 (2_EGF_CA)
PF11598 (COMP)
GO:0005178 (enables) integrin binding
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008083 (enables) growth factor activity
GO:0008201 (enables) heparin binding
GO:0001938 (involved in) positive regulation of endothelial cell proliferation
GO:0006986 (involved in) response to unfolded protein
GO:0007155 (involved in) cell adhesion
GO:0007165 (involved in) signal transduction
GO:0016525 (involved in) negative regulation of angiogenesis
GO:0034103 (involved in) regulation of tissue remodeling
GO:0034976 (involved in) response to endoplasmic reticulum stress
GO:0048266 (involved in) behavioral response to pain
GO:0048771 (involved in) tissue remodeling
GO:0050731 (involved in) positive regulation of peptidyl-tyrosine phosphorylation
GO:0051451 (involved in) myoblast migration
GO:0051781 (involved in) positive regulation of cell division
GO:0071603 (involved in) endothelial cell-cell adhesion
GO:0090023 (involved in) positive regulation of neutrophil chemotaxis
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005615 (located in) extracellular space
GO:0005783 (located in) endoplasmic reticulum
GO:0016529 (located in) sarcoplasmic reticulum
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)