Click here to access PB0142 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0142 O00468 Agrin AGRN AGRIN, CMS8, CMSPPD Homo_sapiens Agrin C-terminal 22 kDa fragment: this released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the number of filopodia.

DomainsGene Ontology
PF00008 (2_EGF)
PF00050 (Kazal_1)
PF00053 (2_Laminin_EGF)
PF00054 (3_Laminin_G_1)
PF01390 (SEA)
PF03146 (NtA)
PF07648 (8_Kazal_2)
GO:0002162 (enables) dystroglycan binding
GO:0005200 (enables) structural constituent of cytoskeleton
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0033691 (enables) sialic acid binding
GO:0035374 (enables) chondroitin sulfate binding
GO:0043236 (enables) laminin binding
GO:0043395 (enables) heparan sulfate proteoglycan binding
GO:0007010 (involved in) cytoskeleton organization
GO:0007165 (involved in) signal transduction
GO:0007213 (involved in) G protein-coupled acetylcholine receptor signaling pathway
GO:0007528 (involved in) neuromuscular junction development
GO:0009887 (involved in) animal organ morphogenesis
GO:0009888 (involved in) tissue development
GO:0030154 (involved in) cell differentiation
GO:0043113 (involved in) receptor clustering
GO:0043547 (involved in) positive regulation of GTPase activity
GO:0045162 (involved in) clustering of voltage-gated sodium channels
GO:0045887 (involved in) positive regulation of synaptic assembly at neuromuscular junction
GO:0045944 (involved in) positive regulation of transcription by RNA polymerase II
GO:0050808 (involved in) synapse organization
GO:0051491 (involved in) positive regulation of filopodium assembly
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005796 (located in) Golgi lumen
GO:0005886 (located in) plasma membrane
GO:0016020 (located in) membrane
GO:0016021 (located in) integral component of membrane
GO:0030054 (located in) cell junction
GO:0043202 (located in) lysosomal lumen
GO:0045202 (located in) synapse
GO:0070062 (located in) extracellular exosome
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)