Click here to access PB0139 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0139 P24821 Tenascin TNC 150-225, DFNA56, GMEM, GP, HXB, JI, TN, TN-C, tenascin C Homo_sapiens Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).

DomainsGene Ontology
PF00041 (15_fn3)
PF00147 (Fibrinogen_C)
PF07974 (4_EGF_2)
PF18720 (9_EGF_Tenascin)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0045545 (enables) syndecan binding
GO:0001558 (involved in) regulation of cell growth
GO:0001649 (involved in) osteoblast differentiation
GO:0002009 (involved in) morphogenesis of an epithelium
GO:0007155 (involved in) cell adhesion
GO:0007528 (involved in) neuromuscular junction development
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0009611 (involved in) response to wounding
GO:0010628 (involved in) positive regulation of gene expression
GO:0014012 (involved in) peripheral nervous system axon regeneration
GO:0030155 (involved in) regulation of cell adhesion
GO:0030334 (involved in) regulation of cell migration
GO:0042127 (involved in) regulation of cell population proliferation
GO:0050727 (involved in) regulation of inflammatory response
GO:0060739 (involved in) mesenchymal-epithelial cell signaling involved in prostate gland development
GO:0060740 (involved in) prostate gland epithelium morphogenesis
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005614 (located in) interstitial matrix
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005925 (located in) focal adhesion
GO:0016020 (located in) membrane
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0090733 (located in) tenascin complex
GO:0098966 (located in) perisynaptic extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)