Click here to access PB0135 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0135 Q16787 Laminin subunit alpha-3 LAMA3 BM600, E170, LAMNA, LOCS Homo_sapiens Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.

DomainsGene Ontology
PF00052 (Laminin_B)
PF00053 (12_Laminin_EGF)
PF00054 (Laminin_G_1)
PF00055 (Laminin_N)
PF02210 (4_Laminin_G_2)
PF06008 (Laminin_I)
PF06009 (Laminin_II)
GO:0005102 (enables) signaling receptor binding
GO:0005178 (enables) integrin binding
GO:0005198 (enables) structural molecule activity
GO:0005201 (enables) extracellular matrix structural constituent
GO:0001738 (involved in) morphogenesis of a polarized epithelium
GO:0007155 (involved in) cell adhesion
GO:0007229 (involved in) integrin-mediated signaling pathway
GO:0007411 (involved in) axon guidance
GO:0008544 (involved in) epidermis development
GO:0009887 (involved in) animal organ morphogenesis
GO:0009888 (involved in) tissue development
GO:0016477 (involved in) cell migration
GO:0030155 (involved in) regulation of cell adhesion
GO:0030334 (involved in) regulation of cell migration
GO:0035987 (involved in) endodermal cell differentiation
GO:0045995 (involved in) regulation of embryonic development
GO:0098609 (involved in) cell-cell adhesion
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005783 (located in) endoplasmic reticulum
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0005610 (part of) laminin-5 complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)