Click here to access PB0132 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0132 P05121 Plasminogen activator inhibitor 1 SERPINE1 PAI, PAI-1, PAI1, PLANH1, serpin family E member 1 Homo_sapiens Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084).

DomainsGene Ontology
PF00079 (Serpin)
GO:0002020 (enables) protease binding
GO:0004867 (enables) serine-type endopeptidase inhibitor activity
GO:0005102 (enables) signaling receptor binding
GO:0005515 (enables) protein binding
GO:0030414 (enables) peptidase inhibitor activity
GO:0001525 (involved in) angiogenesis
GO:0010466 (involved in) negative regulation of peptidase activity
GO:0010469 (involved in) regulation of signaling receptor activity
GO:0010757 (involved in) negative regulation of plasminogen activation
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0014912 (involved in) negative regulation of smooth muscle cell migration
GO:0030194 (involved in) positive regulation of blood coagulation
GO:0030195 (involved in) negative regulation of blood coagulation
GO:0030336 (involved in) negative regulation of cell migration
GO:0032757 (involved in) positive regulation of interleukin-8 production
GO:0033629 (involved in) negative regulation of cell adhesion mediated by integrin
GO:0035491 (involved in) positive regulation of leukotriene production involved in inflammatory response
GO:0042730 (involved in) fibrinolysis
GO:0045766 (involved in) positive regulation of angiogenesis
GO:0048260 (involved in) positive regulation of receptor-mediated endocytosis
GO:0050729 (involved in) positive regulation of inflammatory response
GO:0050829 (involved in) defense response to Gram-negative bacterium
GO:0051918 (involved in) negative regulation of fibrinolysis
GO:0061044 (involved in) negative regulation of vascular wound healing
GO:0061045 (involved in) negative regulation of wound healing
GO:0071222 (involved in) cellular response to lipopolysaccharide
GO:0090026 (involved in) positive regulation of monocyte chemotaxis
GO:0090399 (involved in) replicative senescence
GO:0097187 (involved in) dentinogenesis
GO:1901331 (involved in) positive regulation of odontoblast differentiation
GO:1902042 (involved in) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000098 (involved in) negative regulation of smooth muscle cell-matrix adhesion
GO:2000352 (involved in) negative regulation of endothelial cell apoptotic process
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005886 (located in) plasma membrane
GO:0031093 (located in) platelet alpha granule lumen
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0097180 (located in) serine protease inhibitor complex
GO:1904090 (located in) peptidase inhibitor complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)