Click here to access PB0131 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0131 O94813 Slit homolog 2 protein SLIT2 SLIL3, Slit-2, slit guidance ligand 2 Homo_sapiens Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal chord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration.

DomainsGene Ontology
PF00008 (5_EGF)
PF00054 (Laminin_G_1)
PF01462 (3_LRRNT)
PF01463 (4_LRRCT)
PF12661 (2_hEGF)
PF13855 (7_LRR_8)
GO:0005095 (enables) GTPase inhibitor activity
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0042802 (enables) identical protein binding
GO:0042803 (enables) protein homodimerization activity
GO:0043237 (enables) laminin-1 binding
GO:0043394 (enables) proteoglycan binding
GO:0048495 (enables) Roundabout binding
GO:0001657 (involved in) ureteric bud development
GO:0001933 (involved in) negative regulation of protein phosphorylation
GO:0002042 (involved in) cell migration involved in sprouting angiogenesis
GO:0002689 (involved in) negative regulation of leukocyte chemotaxis
GO:0003180 (involved in) aortic valve morphogenesis
GO:0003184 (involved in) pulmonary valve morphogenesis
GO:0006935 (involved in) chemotaxis
GO:0007399 (involved in) nervous system development
GO:0007411 (involved in) axon guidance
GO:0008045 (involved in) motor neuron axon guidance
GO:0010593 (involved in) negative regulation of lamellipodium assembly
GO:0010596 (involved in) negative regulation of endothelial cell migration
GO:0014912 (involved in) negative regulation of smooth muscle cell migration
GO:0021836 (involved in) chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0021972 (involved in) corticospinal neuron axon guidance through spinal cord
GO:0030154 (involved in) cell differentiation
GO:0030308 (involved in) negative regulation of cell growth
GO:0030336 (involved in) negative regulation of cell migration
GO:0030837 (involved in) negative regulation of actin filament polymerization
GO:0031290 (involved in) retinal ganglion cell axon guidance
GO:0032870 (involved in) cellular response to hormone stimulus
GO:0035385 (involved in) Roundabout signaling pathway
GO:0043065 (involved in) positive regulation of apoptotic process
GO:0043086 (involved in) negative regulation of catalytic activity
GO:0043116 (involved in) negative regulation of vascular permeability
GO:0048754 (involved in) branching morphogenesis of an epithelial tube
GO:0048846 (involved in) axon extension involved in axon guidance
GO:0050772 (involved in) positive regulation of axonogenesis
GO:0050919 (involved in) negative chemotaxis
GO:0050929 (involved in) induction of negative chemotaxis
GO:0051058 (involved in) negative regulation of small GTPase mediated signal transduction
GO:0051414 (involved in) response to cortisol
GO:0060412 (involved in) ventricular septum morphogenesis
GO:0061364 (involved in) apoptotic process involved in luteolysis
GO:0070100 (involved in) negative regulation of chemokine-mediated signaling pathway
GO:0071504 (involved in) cellular response to heparin
GO:0071672 (involved in) negative regulation of smooth muscle cell chemotaxis
GO:0071676 (involved in) negative regulation of mononuclear cell migration
GO:0090024 (involved in) negative regulation of neutrophil chemotaxis
GO:0090027 (involved in) negative regulation of monocyte chemotaxis
GO:0090260 (involved in) negative regulation of retinal ganglion cell axon guidance
GO:0090288 (involved in) negative regulation of cellular response to growth factor stimulus
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005737 (located in) cytoplasm
GO:0016020 (located in) membrane
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)