Click here to access PB0130 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0130 Q8TB73 Protein NDNF NDNF C4orf31, HH25, NORD, neuron derived neurotrophic factor Homo_sapiens Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764).

DomainsGene Ontology
PF10179 (DUF2369)
GO:0005539 (enables) glycosaminoglycan binding
GO:0008201 (enables) heparin binding
GO:0001525 (involved in) angiogenesis
GO:0001764 (involved in) neuron migration
GO:0002931 (involved in) response to ischemia
GO:0007263 (involved in) nitric oxide mediated signal transduction
GO:0007399 (involved in) nervous system development
GO:0010811 (involved in) positive regulation of cell-substrate adhesion
GO:0010976 (involved in) positive regulation of neuron projection development
GO:0019800 (involved in) peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
GO:0021828 (involved in) gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0030198 (involved in) extracellular matrix organization
GO:0043524 (involved in) negative regulation of neuron apoptotic process
GO:0044344 (involved in) cellular response to fibroblast growth factor stimulus
GO:0061042 (involved in) vascular wound healing
GO:0071456 (involved in) cellular response to hypoxia
GO:2000352 (involved in) negative regulation of endothelial cell apoptotic process
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0031012 (located in) extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)