Click here to access PB0129 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0129 P02458 Collagen alpha-1(II) chain COL2A1 ANFH, AOM, COL11A3, SEDC, STL1, collagen type II alpha 1 chain Homo_sapiens Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.

DomainsGene Ontology
PF00093 (VWC)
PF01391 (6_Collagen)
PF01410 (COLFI)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0030020 (enables) extracellular matrix structural constituent conferring tensile strength
GO:0042289 (enables) MHC class II protein binding
GO:0042802 (enables) identical protein binding
GO:0043394 (enables) proteoglycan binding
GO:0046872 (enables) metal ion binding
GO:0048407 (enables) platelet-derived growth factor binding
GO:0001501 (involved in) skeletal system development
GO:0001502 (involved in) cartilage condensation
GO:0001503 (involved in) ossification
GO:0001894 (involved in) tissue homeostasis
GO:0001958 (involved in) endochondral ossification
GO:0002062 (involved in) chondrocyte differentiation
GO:0003007 (involved in) heart morphogenesis
GO:0006029 (involved in) proteoglycan metabolic process
GO:0007417 (involved in) central nervous system development
GO:0007601 (involved in) visual perception
GO:0007605 (involved in) sensory perception of sound
GO:0010468 (involved in) regulation of gene expression
GO:0030198 (involved in) extracellular matrix organization
GO:0030199 (involved in) collagen fibril organization
GO:0030903 (involved in) notochord development
GO:0035108 (involved in) limb morphogenesis
GO:0042472 (involved in) inner ear morphogenesis
GO:0048705 (involved in) skeletal system morphogenesis
GO:0048839 (involved in) inner ear development
GO:0051216 (involved in) cartilage development
GO:0060021 (involved in) roof of mouth development
GO:0060174 (involved in) limb bud formation
GO:0060272 (involved in) embryonic skeletal joint morphogenesis
GO:0060348 (involved in) bone development
GO:0060351 (involved in) cartilage development involved in endochondral bone morphogenesis
GO:0071599 (involved in) otic vesicle development
GO:0071773 (involved in) cellular response to BMP stimulus
GO:0097065 (involved in) anterior head development
GO:2001240 (involved in) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0005615 (is active in) extracellular space
GO:0031012 (is active in) extracellular matrix
GO:0005576 (located in) extracellular region
GO:0005592 (located in) collagen type XI trimer
GO:0005604 (located in) basement membrane
GO:0005737 (located in) cytoplasm
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005581 (part of) collagen trimer
GO:0005585 (part of) collagen type II trimer
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)