Click here to access PB0128 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0128 P07942 Laminin subunit beta-1 LAMB1 CLM, LIS5 Homo_sapiens Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface.

DomainsGene Ontology
PF00053 (13_Laminin_EGF)
PF00055 (Laminin_N)
GO:0005178 (enables) integrin binding
GO:0005198 (enables) structural molecule activity
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0007155 (involved in) cell adhesion
GO:0009887 (involved in) animal organ morphogenesis
GO:0009888 (involved in) tissue development
GO:0016477 (involved in) cell migration
GO:0021812 (involved in) neuronal-glial interaction involved in cerebral cortex radial glia guided migration
GO:0030335 (involved in) positive regulation of cell migration
GO:0031175 (involved in) neuron projection development
GO:0034446 (involved in) substrate adhesion-dependent cell spreading
GO:0035987 (involved in) endodermal cell differentiation
GO:0042476 (involved in) odontogenesis
GO:0045785 (involved in) positive regulation of cell adhesion
GO:0050679 (involved in) positive regulation of epithelial cell proliferation
GO:0051149 (involved in) positive regulation of muscle cell differentiation
GO:0070831 (involved in) basement membrane assembly
GO:0110011 (involved in) regulation of basement membrane organization
GO:2001046 (involved in) positive regulation of integrin-mediated signaling pathway
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0048471 (located in) perinuclear region of cytoplasm
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0098637 (located in) protein complex involved in cell-matrix adhesion
GO:0005606 (part of) laminin-1 complex
GO:0005607 (part of) laminin-2 complex
GO:0043256 (part of) laminin complex
GO:0043257 (part of) laminin-8 complex
GO:0043259 (part of) laminin-10 complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)