Click here to access PB0125 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0125 Q02818 Nucleobindin-1 NUCB1 CALNUC, NUC Homo_sapiens Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity).

DomainsGene Ontology
PF13499 (EF-hand_7)
GO:0001965 (enables) G-protein alpha-subunit binding
GO:0003677 (enables) DNA binding
GO:0005085 (enables) guanyl-nucleotide exchange factor activity
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0046872 (enables) metal ion binding
GO:0007264 (involved in) small GTPase mediated signal transduction
GO:0050790 (involved in) regulation of catalytic activity
GO:0005793 (is active in) endoplasmic reticulum-Golgi intermediate compartment
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005737 (located in) cytoplasm
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005794 (located in) Golgi apparatus
GO:0016020 (located in) membrane
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)