Click here to access PB0123 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0123 O15230 Laminin subunit alpha-5 LAMA5 Homo_sapiens Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

DomainsGene Ontology
PF00052 (1_Laminin_B)
PF00053 (19_Laminin_EGF)
PF00055 (Laminin_N)
PF02210 (4_Laminin_G_2)
PF06008 (Laminin_I)
PF06009 (Laminin_II)
GO:0005102 (enables) signaling receptor binding
GO:0005178 (enables) integrin binding
GO:0005201 (enables) extracellular matrix structural constituent
GO:0001658 (involved in) branching involved in ureteric bud morphogenesis
GO:0001738 (involved in) morphogenesis of a polarized epithelium
GO:0001755 (involved in) neural crest cell migration
GO:0001822 (involved in) kidney development
GO:0001942 (involved in) hair follicle development
GO:0007155 (involved in) cell adhesion
GO:0007229 (involved in) integrin-mediated signaling pathway
GO:0007411 (involved in) axon guidance
GO:0007517 (involved in) muscle organ development
GO:0009887 (involved in) animal organ morphogenesis
GO:0009888 (involved in) tissue development
GO:0016331 (involved in) morphogenesis of embryonic epithelium
GO:0016477 (involved in) cell migration
GO:0030155 (involved in) regulation of cell adhesion
GO:0030324 (involved in) lung development
GO:0030334 (involved in) regulation of cell migration
GO:0034446 (involved in) substrate adhesion-dependent cell spreading
GO:0042127 (involved in) regulation of cell population proliferation
GO:0042475 (involved in) odontogenesis of dentin-containing tooth
GO:0045995 (involved in) regulation of embryonic development
GO:0048754 (involved in) branching morphogenesis of an epithelial tube
GO:0060271 (involved in) cilium assembly
GO:0060445 (involved in) branching involved in salivary gland morphogenesis
GO:0072659 (involved in) protein localization to plasma membrane
GO:0098609 (involved in) cell-cell adhesion
GO:0005604 (is active in) basement membrane
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005634 (located in) nucleus
GO:0031012 (located in) extracellular matrix
GO:0031594 (located in) neuromuscular junction
GO:0043083 (located in) synaptic cleft
GO:0070062 (located in) extracellular exosome
GO:0005610 (part of) laminin-5 complex
GO:0043259 (part of) laminin-10 complex
GO:0043260 (part of) laminin-11 complex
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)