Click here to access PB0121 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0121 O75443 Alpha-tectorin TECTA DFNA12, DFNA8, DFNB21, tectorin alpha Homo_sapiens The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.

DomainsGene Ontology
PF00094 (4_VWD)
PF00100 (Zona_pellucida)
PF01826 (3_TIL)
PF06119 (NIDO)
PF08742 (4_C8)
PF12714 (2_TILa)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0007160 (involved in) cell-matrix adhesion
GO:0007605 (involved in) sensory perception of sound
GO:0005576 (located in) extracellular region
GO:0005886 (located in) plasma membrane
GO:0016020 (located in) membrane
GO:0031012 (located in) extracellular matrix
GO:0031225 (located in) anchored component of membrane
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)