Click here to access PB0120 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0120 P07225 Vitamin K-dependent protein S PROS1 PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6, protein S Homo_sapiens Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

DomainsGene Ontology
PF00008 (EGF)
PF00054 (Laminin_G_1)
PF00594 (Gla)
PF02210 (Laminin_G_2)
PF07645 (2_EGF_CA)
GO:0004866 (enables) endopeptidase inhibitor activity
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0007596 (involved in) blood coagulation
GO:0007599 (involved in) hemostasis
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0030195 (involved in) negative regulation of blood coagulation
GO:0042730 (involved in) fibrinolysis
GO:0005615 (is active in) extracellular space
GO:0000139 (located in) Golgi membrane
GO:0005576 (located in) extracellular region
GO:0005789 (located in) endoplasmic reticulum membrane
GO:0005796 (located in) Golgi lumen
GO:0005886 (located in) plasma membrane
GO:0031093 (located in) platelet alpha granule lumen
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)