Click here to access PB0119 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0119 Q5T4F7 Secreted frizzled-related protein 5 SFRP5 SARP3 Homo_sapiens Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

DomainsGene Ontology
PF01392 (Fz)
PF01759 (NTR)
GO:0017147 (enables) Wnt-protein binding
GO:0006915 (involved in) apoptotic process
GO:0007163 (involved in) establishment or maintenance of cell polarity
GO:0007165 (involved in) signal transduction
GO:0007601 (involved in) visual perception
GO:0008285 (involved in) negative regulation of cell population proliferation
GO:0009653 (involved in) anatomical structure morphogenesis
GO:0016055 (involved in) Wnt signaling pathway
GO:0030111 (involved in) regulation of Wnt signaling pathway
GO:0030154 (involved in) cell differentiation
GO:0030178 (involved in) negative regulation of Wnt signaling pathway
GO:0030510 (involved in) regulation of BMP signaling pathway
GO:0043433 (involved in) negative regulation of DNA-binding transcription factor activity
GO:0051898 (involved in) negative regulation of protein kinase B signaling
GO:0060070 (involved in) canonical Wnt signaling pathway
GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway
GO:2000057 (involved in) negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)