Click here to access PB0118 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0118 P06681 Complement C2 C2 ARMD14, CO2 Homo_sapiens Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.

DomainsGene Ontology
PF00084 (2_Sushi)
PF00089 (Trypsin)
PF00092 (VWA)
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005515 (enables) protein binding
GO:0008233 (enables) peptidase activity
GO:0008236 (enables) serine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0046872 (enables) metal ion binding
GO:0002376 (involved in) immune system process
GO:0006508 (involved in) proteolysis
GO:0006956 (involved in) complement activation
GO:0006958 (involved in) complement activation, classical pathway
GO:0032496 (involved in) response to lipopolysaccharide
GO:0045087 (involved in) innate immune response
GO:0097066 (involved in) response to thyroid hormone
GO:2000427 (involved in) positive regulation of apoptotic cell clearance
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)