Click here to access PB0117 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0117 Q13753 Laminin subunit gamma-2 LAMC2 B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2 Homo_sapiens Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.

DomainsGene Ontology
PF00052 (Laminin_B)
PF00053 (7_Laminin_EGF)
GO:0005102 (enables) signaling receptor binding
GO:0005201 (enables) extracellular matrix structural constituent
GO:0008201 (enables) heparin binding
GO:0007155 (involved in) cell adhesion
GO:0008045 (involved in) motor neuron axon guidance
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0008544 (involved in) epidermis development
GO:0009887 (involved in) animal organ morphogenesis
GO:0009888 (involved in) tissue development
GO:0016358 (involved in) dendrite development
GO:0030335 (involved in) positive regulation of cell migration
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005615 (located in) extracellular space
GO:0005938 (located in) cell cortex
GO:0016020 (located in) membrane
GO:0031012 (located in) extracellular matrix
GO:0048471 (located in) perinuclear region of cytoplasm
GO:0005607 (part of) laminin-2 complex
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)