Click here to access PB0116 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0116 P04004 Vitronectin VTN V75, VN, VNT Homo_sapiens Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.

DomainsGene Ontology
PF00045 (4_Hemopexin)
PF01033 (Somatomedin_B)
GO:0005044 (enables) scavenger receptor activity
GO:0005178 (enables) integrin binding
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0030247 (enables) polysaccharide binding
GO:0050840 (enables) extracellular matrix binding
GO:0006897 (involved in) endocytosis
GO:0006955 (involved in) immune response
GO:0007155 (involved in) cell adhesion
GO:0007160 (involved in) cell-matrix adhesion
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0014911 (involved in) positive regulation of smooth muscle cell migration
GO:0016477 (involved in) cell migration
GO:0030155 (involved in) regulation of cell adhesion
GO:0030195 (involved in) negative regulation of blood coagulation
GO:0030949 (involved in) positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032092 (involved in) positive regulation of protein binding
GO:0033627 (involved in) cell adhesion mediated by integrin
GO:0035987 (involved in) endodermal cell differentiation
GO:0048260 (involved in) positive regulation of receptor-mediated endocytosis
GO:0050731 (involved in) positive regulation of peptidyl-tyrosine phosphorylation
GO:0051918 (involved in) negative regulation of fibrinolysis
GO:0061302 (involved in) smooth muscle cell-matrix adhesion
GO:0090303 (involved in) positive regulation of wound healing
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005783 (located in) endoplasmic reticulum
GO:0043231 (located in) intracellular membrane-bounded organelle
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle
GO:0098637 (located in) protein complex involved in cell-matrix adhesion
GO:1904090 (located in) peptidase inhibitor complex
GO:0071062 (part of) alphav-beta3 integrin-vitronectin complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)