Click here to access PB0114 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0114 Q14393 Growth arrest-specific protein 6 GAS6 AXLLG, AXSF, growth arrest specific 6 Homo_sapiens Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).

DomainsGene Ontology
PF00054 (Laminin_G_1)
PF00594 (Gla)
PF02210 (Laminin_G_2)
PF07645 (EGF_CA)
PF12661 (2_hEGF)
PF12662 (cEGF)
GO:0070374 (acts upstream of or within) positive regulation of ERK1 and ERK2 cascade
GO:0001786 (enables) phosphatidylserine binding
GO:0005102 (enables) signaling receptor binding
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0030296 (enables) protein tyrosine kinase activator activity
GO:0030674 (enables) protein-macromolecule adaptor activity
GO:0030971 (enables) receptor tyrosine kinase binding
GO:0043027 (enables) cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872 (enables) metal ion binding
GO:0048018 (enables) receptor ligand activity
GO:0001764 (involved in) neuron migration
GO:0001934 (involved in) positive regulation of protein phosphorylation
GO:0001961 (involved in) positive regulation of cytokine-mediated signaling pathway
GO:0003104 (involved in) positive regulation of glomerular filtration
GO:0006468 (involved in) protein phosphorylation
GO:0006909 (involved in) phagocytosis
GO:0006915 (involved in) apoptotic process
GO:0007165 (involved in) signal transduction
GO:0007167 (involved in) enzyme linked receptor protein signaling pathway
GO:0007596 (involved in) blood coagulation
GO:0009267 (involved in) cellular response to starvation
GO:0010628 (involved in) positive regulation of gene expression
GO:0010804 (involved in) negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0018105 (involved in) peptidyl-serine phosphorylation
GO:0019064 (involved in) fusion of virus membrane with host plasma membrane
GO:0019079 (involved in) viral genome replication
GO:0031100 (involved in) animal organ regeneration
GO:0031589 (involved in) cell-substrate adhesion
GO:0032008 (involved in) positive regulation of TOR signaling
GO:0032148 (involved in) activation of protein kinase B activity
GO:0032689 (involved in) negative regulation of interferon-gamma production
GO:0032692 (involved in) negative regulation of interleukin-1 production
GO:0032715 (involved in) negative regulation of interleukin-6 production
GO:0032720 (involved in) negative regulation of tumor necrosis factor production
GO:0032825 (involved in) positive regulation of natural killer cell differentiation
GO:0033138 (involved in) positive regulation of peptidyl-serine phosphorylation
GO:0035457 (involved in) cellular response to interferon-alpha
GO:0035754 (involved in) B cell chemotaxis
GO:0040008 (involved in) regulation of growth
GO:0043066 (involved in) negative regulation of apoptotic process
GO:0043154 (involved in) negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043277 (involved in) apoptotic cell clearance
GO:0043433 (involved in) negative regulation of DNA-binding transcription factor activity
GO:0043491 (involved in) protein kinase B signaling
GO:0045860 (involved in) positive regulation of protein kinase activity
GO:0045892 (involved in) negative regulation of transcription, DNA-templated
GO:0046718 (involved in) viral entry into host cell
GO:0046813 (involved in) receptor-mediated virion attachment to host cell
GO:0046827 (involved in) positive regulation of protein export from nucleus
GO:0048146 (involved in) positive regulation of fibroblast proliferation
GO:0050766 (involved in) positive regulation of phagocytosis
GO:0051897 (involved in) positive regulation of protein kinase B signaling
GO:0061098 (involved in) positive regulation of protein tyrosine kinase activity
GO:0070168 (involved in) negative regulation of biomineral tissue development
GO:0070588 (involved in) calcium ion transmembrane transport
GO:0071307 (involved in) cellular response to vitamin K
GO:0071333 (involved in) cellular response to glucose stimulus
GO:0071363 (involved in) cellular response to growth factor stimulus
GO:0071466 (involved in) cellular response to xenobiotic stimulus
GO:0072659 (involved in) protein localization to plasma membrane
GO:0085029 (involved in) extracellular matrix assembly
GO:0097028 (involved in) dendritic cell differentiation
GO:0097241 (involved in) hematopoietic stem cell migration to bone marrow
GO:1900142 (involved in) negative regulation of oligodendrocyte apoptotic process
GO:2000270 (involved in) negative regulation of fibroblast apoptotic process
GO:2000352 (involved in) negative regulation of endothelial cell apoptotic process
GO:2000510 (involved in) positive regulation of dendritic cell chemotaxis
GO:2000533 (involved in) negative regulation of renal albumin absorption
GO:2000669 (involved in) negative regulation of dendritic cell apoptotic process
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005737 (located in) cytoplasm
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005796 (located in) Golgi lumen
GO:0031093 (located in) platelet alpha granule lumen
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)