Click here to access PB0111 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0111 Q9NS15 Latent-transforming growth factor beta-binding protein 3 LTBP3 DASS, GPHYSD3, LTBP-3, LTBP2, STHAG6, pp6425 Homo_sapiens Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.

DomainsGene Ontology
PF00683 (4_TB)
PF07645 (9_EGF_CA)
PF12662 (2_cEGF)
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0019838 (enables) growth factor binding
GO:0050431 (enables) transforming growth factor beta binding
GO:0001501 (involved in) skeletal system development
GO:0007179 (involved in) transforming growth factor beta receptor signaling pathway
GO:0030502 (involved in) negative regulation of bone mineralization
GO:0032331 (involved in) negative regulation of chondrocyte differentiation
GO:0036363 (involved in) transforming growth factor beta activation
GO:0045780 (involved in) positive regulation of bone resorption
GO:0046849 (involved in) bone remodeling
GO:0048251 (involved in) elastic fiber assembly
GO:0060349 (involved in) bone morphogenesis
GO:0060430 (involved in) lung saccule development
GO:1902462 (involved in) positive regulation of mesenchymal stem cell proliferation
GO:2000741 (involved in) positive regulation of mesenchymal stem cell differentiation
GO:0005576 (located in) extracellular region
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)