Click here to access PB0110 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0110 P08709 Coagulation factor VII F7 SPCA Homo_sapiens Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.

DomainsGene Ontology
PF00008 (EGF)
PF00089 (Trypsin)
PF00594 (Gla)
GO:0004175 (enables) endopeptidase activity
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005102 (enables) signaling receptor binding
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008233 (enables) peptidase activity
GO:0008236 (enables) serine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0001666 (involved in) response to hypoxia
GO:0002690 (involved in) positive regulation of leukocyte chemotaxis
GO:0006508 (involved in) proteolysis
GO:0007596 (involved in) blood coagulation
GO:0007599 (involved in) hemostasis
GO:0007623 (involved in) circadian rhythm
GO:0009725 (involved in) response to hormone
GO:0010037 (involved in) response to carbon dioxide
GO:0010641 (involved in) positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0014070 (involved in) response to organic cyclic compound
GO:0016485 (involved in) protein processing
GO:0030194 (involved in) positive regulation of blood coagulation
GO:0030335 (involved in) positive regulation of cell migration
GO:0031100 (involved in) animal organ regeneration
GO:0031667 (involved in) response to nutrient levels
GO:0032355 (involved in) response to estradiol
GO:0032571 (involved in) response to vitamin K
GO:0033595 (involved in) response to genistein
GO:0043627 (involved in) response to estrogen
GO:0050927 (involved in) positive regulation of positive chemotaxis
GO:0051897 (involved in) positive regulation of protein kinase B signaling
GO:0060416 (involved in) response to growth hormone
GO:0061476 (involved in) response to anticoagulant
GO:0070723 (involved in) response to cholesterol
GO:0097066 (involved in) response to thyroid hormone
GO:0097068 (involved in) response to thyroxine
GO:1904400 (involved in) response to Thyroid stimulating hormone
GO:1904612 (involved in) response to 2,3,7,8-tetrachlorodibenzodioxine
GO:1905217 (involved in) response to astaxanthin
GO:1905225 (involved in) response to thyrotropin-releasing hormone
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005796 (located in) Golgi lumen
GO:0005886 (located in) plasma membrane
GO:0031982 (located in) vesicle
GO:0062023 (part of) collagen-containing extracellular matrix
GO:1905286 (part of) serine-type peptidase complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)