Click here to access PB0107 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0107 P14780 Matrix metalloproteinase-9 MMP9 CLG4B, GELB, MANDP2, MMP-9 Homo_sapiens Degrades fibronectin but not laminin or Pz-peptide.

DomainsGene Ontology
PF00040 (3_fn2)
PF00045 (4_Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)
GO:0004175 (enables) endopeptidase activity
GO:0004222 (enables) metalloendopeptidase activity
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005515 (enables) protein binding
GO:0005518 (enables) collagen binding
GO:0008233 (enables) peptidase activity
GO:0008237 (enables) metallopeptidase activity
GO:0008270 (enables) zinc ion binding
GO:0016787 (enables) hydrolase activity
GO:0042802 (enables) identical protein binding
GO:0046872 (enables) metal ion binding
GO:0001501 (involved in) skeletal system development
GO:0001503 (involved in) ossification
GO:0001934 (involved in) positive regulation of protein phosphorylation
GO:0006508 (involved in) proteolysis
GO:0007566 (involved in) embryo implantation
GO:0022617 (involved in) extracellular matrix disassembly
GO:0030198 (involved in) extracellular matrix organization
GO:0030225 (involved in) macrophage differentiation
GO:0030335 (involved in) positive regulation of cell migration
GO:0030574 (involved in) collagen catabolic process
GO:0034614 (involved in) cellular response to reactive oxygen species
GO:0035987 (involved in) endodermal cell differentiation
GO:0043065 (involved in) positive regulation of apoptotic process
GO:0043066 (involved in) negative regulation of apoptotic process
GO:0043388 (involved in) positive regulation of DNA binding
GO:0045742 (involved in) positive regulation of epidermal growth factor receptor signaling pathway
GO:0048013 (involved in) ephrin receptor signaling pathway
GO:0050900 (involved in) leukocyte migration
GO:0051549 (involved in) positive regulation of keratinocyte migration
GO:0071276 (involved in) cellular response to cadmium ion
GO:0071492 (involved in) cellular response to UV-A
GO:0090200 (involved in) positive regulation of release of cytochrome c from mitochondria
GO:0150077 (involved in) regulation of neuroinflammatory response
GO:1900122 (involved in) positive regulation of receptor binding
GO:1904645 (involved in) response to amyloid-beta
GO:1904707 (involved in) positive regulation of vascular associated smooth muscle cell proliferation
GO:2000697 (involved in) negative regulation of epithelial cell differentiation involved in kidney development
GO:2001243 (involved in) negative regulation of intrinsic apoptotic signaling pathway
GO:2001258 (involved in) negative regulation of cation channel activity
GO:2001268 (involved in) negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0031012 (located in) extracellular matrix
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:1904724 (located in) tertiary granule lumen
GO:1904813 (located in) ficolin-1-rich granule lumen

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)