Click here to access PB0106 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0106 O15444 C-C motif chemokine 25 CCL25 Ck beta-15, Ckb15, SCYA25, TECK, C-C motif chemokine ligand 25 Homo_sapiens Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.

DomainsGene Ontology
PF00048 (IL8)
GO:0005125 (enables) cytokine activity
GO:0005179 (enables) hormone activity
GO:0005515 (enables) protein binding
GO:0008009 (enables) chemokine activity
GO:0031735 (enables) CCR10 chemokine receptor binding
GO:0042379 (enables) chemokine receptor binding
GO:0048020 (enables) CCR chemokine receptor binding
GO:0001954 (involved in) positive regulation of cell-matrix adhesion
GO:0002548 (involved in) monocyte chemotaxis
GO:0006935 (involved in) chemotaxis
GO:0006954 (involved in) inflammatory response
GO:0006955 (involved in) immune response
GO:0007166 (involved in) cell surface receptor signaling pathway
GO:0007186 (involved in) G protein-coupled receptor signaling pathway
GO:0030593 (involved in) neutrophil chemotaxis
GO:0043547 (involved in) positive regulation of GTPase activity
GO:0048247 (involved in) lymphocyte chemotaxis
GO:0060326 (involved in) cell chemotaxis
GO:0070098 (involved in) chemokine-mediated signaling pathway
GO:0070374 (involved in) positive regulation of ERK1 and ERK2 cascade
GO:0071346 (involved in) cellular response to interferon-gamma
GO:0071347 (involved in) cellular response to interleukin-1
GO:0071356 (involved in) cellular response to tumor necrosis factor
GO:1903237 (involved in) negative regulation of leukocyte tethering or rolling
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)