Click here to access PB0103 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0103 Q641Q3 Meteorin-like protein METRNL meteorin like, glial cell differentiation regulator Homo_sapiens Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity).

DomainsGene Ontology
GO:0003674 (enables) molecular_function
GO:0005179 (enables) hormone activity
GO:0007165 (involved in) signal transduction
GO:0009409 (involved in) response to cold
GO:0014850 (involved in) response to muscle activity
GO:0045444 (involved in) fat cell differentiation
GO:0050728 (involved in) negative regulation of inflammatory response
GO:0050873 (involved in) brown fat cell differentiation
GO:0090336 (involved in) positive regulation of brown fat cell differentiation
GO:0097009 (involved in) energy homeostasis
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)