Click here to access PB0100 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0100 P43235 Cathepsin K CTSK CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD Homo_sapiens Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).

DomainsGene Ontology
PF00112 (Peptidase_C1)
PF08246 (Inhibitor_I29)
GO:0001968 (enables) fibronectin binding
GO:0004197 (enables) cysteine-type endopeptidase activity
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005515 (enables) protein binding
GO:0005518 (enables) collagen binding
GO:0008233 (enables) peptidase activity
GO:0008234 (enables) cysteine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0043394 (enables) proteoglycan binding
GO:0000422 (involved in) autophagy of mitochondrion
GO:0001957 (involved in) intramembranous ossification
GO:0006508 (involved in) proteolysis
GO:0006590 (involved in) thyroid hormone generation
GO:0006955 (involved in) immune response
GO:0022617 (involved in) extracellular matrix disassembly
GO:0030574 (involved in) collagen catabolic process
GO:0045453 (involved in) bone resorption
GO:0051603 (involved in) proteolysis involved in cellular protein catabolic process
GO:0061037 (involved in) negative regulation of cartilage development
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005654 (located in) nucleoplasm
GO:0005737 (located in) cytoplasm
GO:0005764 (located in) lysosome
GO:0005886 (located in) plasma membrane
GO:0009897 (located in) external side of plasma membrane
GO:0016020 (located in) membrane
GO:0016324 (located in) apical plasma membrane
GO:0036021 (located in) endolysosome lumen
GO:0043202 (located in) lysosomal lumen
GO:0043231 (located in) intracellular membrane-bounded organelle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)