Click here to access PB0099 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0099 O75339 Cartilage intermediate layer protein 1 CILP CILP-1, HsT18872 Homo_sapiens Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.

DomainsGene Ontology
PF00090 (TSP_1)
PF13330 (Mucin2_WxxW)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0010629 (involved in) negative regulation of gene expression
GO:0043569 (involved in) negative regulation of insulin-like growth factor receptor signaling pathway
GO:0060392 (involved in) negative regulation of SMAD protein signal transduction
GO:0071560 (involved in) cellular response to transforming growth factor beta stimulus
GO:0005615 (is active in) extracellular space
GO:0062023 (is active in) collagen-containing extracellular matrix
GO:0005576 (located in) extracellular region
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)