Click here to access PB0088 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0088 P02655 Apolipoprotein C-II APOC2 APO-CII, APOC-II, apolipoprotein C2 Homo_sapiens Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.

DomainsGene Ontology
PF05355 (Apo-CII)
GO:0005515 (enables) protein binding
GO:0008047 (enables) enzyme activator activity
GO:0008289 (enables) lipid binding
GO:0016004 (enables) phospholipase activator activity
GO:0043274 (enables) phospholipase binding
GO:0055102 (enables) lipase inhibitor activity
GO:0060230 (enables) lipoprotein lipase activator activity
GO:0006629 (involved in) lipid metabolic process
GO:0006869 (involved in) lipid transport
GO:0010518 (involved in) positive regulation of phospholipase activity
GO:0010898 (involved in) positive regulation of triglyceride catabolic process
GO:0010902 (involved in) positive regulation of very-low-density lipoprotein particle remodeling
GO:0010916 (involved in) negative regulation of very-low-density lipoprotein particle clearance
GO:0016042 (involved in) lipid catabolic process
GO:0032375 (involved in) negative regulation of cholesterol transport
GO:0033344 (involved in) cholesterol efflux
GO:0033700 (involved in) phospholipid efflux
GO:0034370 (involved in) triglyceride-rich lipoprotein particle remodeling
GO:0034371 (involved in) chylomicron remodeling
GO:0034372 (involved in) very-low-density lipoprotein particle remodeling
GO:0034382 (involved in) chylomicron remnant clearance
GO:0034384 (involved in) high-density lipoprotein particle clearance
GO:0042632 (involved in) cholesterol homeostasis
GO:0043086 (involved in) negative regulation of catalytic activity
GO:0043691 (involved in) reverse cholesterol transport
GO:0045723 (involved in) positive regulation of fatty acid biosynthetic process
GO:0045833 (involved in) negative regulation of lipid metabolic process
GO:0048261 (involved in) negative regulation of receptor-mediated endocytosis
GO:0051006 (involved in) positive regulation of lipoprotein lipase activity
GO:0060697 (involved in) positive regulation of phospholipid catabolic process
GO:0070328 (involved in) triglyceride homeostasis
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005769 (located in) early endosome
GO:0034361 (part of) very-low-density lipoprotein particle
GO:0034362 (part of) low-density lipoprotein particle
GO:0034363 (part of) intermediate-density lipoprotein particle
GO:0034364 (part of) high-density lipoprotein particle
GO:0034366 (part of) spherical high-density lipoprotein particle
GO:0042627 (part of) chylomicron

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)