Click here to access PB0087 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0087 P02654 Apolipoprotein C-I APOC1 Apo-CI, ApoC-I, apo-CIB, apoC-IB, apolipoprotein C1 Homo_sapiens Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.

DomainsGene Ontology
PF04691 (ApoC-I)
GO:0004859 (enables) phospholipase inhibitor activity
GO:0005504 (enables) fatty acid binding
GO:0005515 (enables) protein binding
GO:0031210 (enables) phosphatidylcholine binding
GO:0055102 (enables) lipase inhibitor activity
GO:0060228 (enables) phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0006629 (involved in) lipid metabolic process
GO:0006641 (involved in) triglyceride metabolic process
GO:0006869 (involved in) lipid transport
GO:0010873 (involved in) positive regulation of cholesterol esterification
GO:0010900 (involved in) negative regulation of phosphatidylcholine catabolic process
GO:0010916 (involved in) negative regulation of very-low-density lipoprotein particle clearance
GO:0032374 (involved in) regulation of cholesterol transport
GO:0032375 (involved in) negative regulation of cholesterol transport
GO:0033344 (involved in) cholesterol efflux
GO:0033700 (involved in) phospholipid efflux
GO:0034369 (involved in) plasma lipoprotein particle remodeling
GO:0034375 (involved in) high-density lipoprotein particle remodeling
GO:0034379 (involved in) very-low-density lipoprotein particle assembly
GO:0034382 (involved in) chylomicron remnant clearance
GO:0034447 (involved in) very-low-density lipoprotein particle clearance
GO:0042157 (involved in) lipoprotein metabolic process
GO:0045717 (involved in) negative regulation of fatty acid biosynthetic process
GO:0045833 (involved in) negative regulation of lipid metabolic process
GO:0048261 (involved in) negative regulation of receptor-mediated endocytosis
GO:0050995 (involved in) negative regulation of lipid catabolic process
GO:0051005 (involved in) negative regulation of lipoprotein lipase activity
GO:0005576 (located in) extracellular region
GO:0005783 (located in) endoplasmic reticulum
GO:0034361 (part of) very-low-density lipoprotein particle
GO:0034364 (part of) high-density lipoprotein particle
GO:0042627 (part of) chylomicron

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)