Click here to access PB0086 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0086 P02647 Apolipoprotein A-I APOA1 HPALP2, apo(a), apolipoprotein A1 Homo_sapiens Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.

DomainsGene Ontology
PF01442 (Apolipoprotein)
GO:0001540 (enables) amyloid-beta binding
GO:0005102 (enables) signaling receptor binding
GO:0005319 (enables) lipid transporter activity
GO:0005515 (enables) protein binding
GO:0005543 (enables) phospholipid binding
GO:0008035 (enables) high-density lipoprotein particle binding
GO:0008289 (enables) lipid binding
GO:0015485 (enables) cholesterol binding
GO:0019899 (enables) enzyme binding
GO:0031072 (enables) heat shock protein binding
GO:0031210 (enables) phosphatidylcholine binding
GO:0034190 (enables) apolipoprotein receptor binding
GO:0034191 (enables) apolipoprotein A-I receptor binding
GO:0042802 (enables) identical protein binding
GO:0045499 (enables) chemorepellent activity
GO:0060228 (enables) phosphatidylcholine-sterol O-acyltransferase activator activity
GO:0070653 (enables) high-density lipoprotein particle receptor binding
GO:0071813 (enables) lipoprotein particle binding
GO:0120020 (enables) cholesterol transfer activity
GO:0001932 (involved in) regulation of protein phosphorylation
GO:0001935 (involved in) endothelial cell proliferation
GO:0002719 (involved in) negative regulation of cytokine production involved in immune response
GO:0006629 (involved in) lipid metabolic process
GO:0006644 (involved in) phospholipid metabolic process
GO:0006656 (involved in) phosphatidylcholine biosynthetic process
GO:0006695 (involved in) cholesterol biosynthetic process
GO:0006869 (involved in) lipid transport
GO:0007186 (involved in) G protein-coupled receptor signaling pathway
GO:0007229 (involved in) integrin-mediated signaling pathway
GO:0008202 (involved in) steroid metabolic process
GO:0008203 (involved in) cholesterol metabolic process
GO:0008211 (involved in) glucocorticoid metabolic process
GO:0010804 (involved in) negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010873 (involved in) positive regulation of cholesterol esterification
GO:0010875 (involved in) positive regulation of cholesterol efflux
GO:0010898 (involved in) positive regulation of triglyceride catabolic process
GO:0010903 (involved in) negative regulation of very-low-density lipoprotein particle remodeling
GO:0018158 (involved in) protein oxidation
GO:0018206 (involved in) peptidyl-methionine modification
GO:0019915 (involved in) lipid storage
GO:0030300 (involved in) regulation of intestinal cholesterol absorption
GO:0030301 (involved in) cholesterol transport
GO:0030325 (involved in) adrenal gland development
GO:0032489 (involved in) regulation of Cdc42 protein signal transduction
GO:0032691 (involved in) negative regulation of interleukin-1 beta production
GO:0033344 (involved in) cholesterol efflux
GO:0033700 (involved in) phospholipid efflux
GO:0034115 (involved in) negative regulation of heterotypic cell-cell adhesion
GO:0034372 (involved in) very-low-density lipoprotein particle remodeling
GO:0034375 (involved in) high-density lipoprotein particle remodeling
GO:0034380 (involved in) high-density lipoprotein particle assembly
GO:0034384 (involved in) high-density lipoprotein particle clearance
GO:0035025 (involved in) positive regulation of Rho protein signal transduction
GO:0042157 (involved in) lipoprotein metabolic process
GO:0042158 (involved in) lipoprotein biosynthetic process
GO:0042632 (involved in) cholesterol homeostasis
GO:0043534 (involved in) blood vessel endothelial cell migration
GO:0043691 (involved in) reverse cholesterol transport
GO:0045723 (involved in) positive regulation of fatty acid biosynthetic process
GO:0046470 (involved in) phosphatidylcholine metabolic process
GO:0046889 (involved in) positive regulation of lipid biosynthetic process
GO:0050728 (involved in) negative regulation of inflammatory response
GO:0050766 (involved in) positive regulation of phagocytosis
GO:0050821 (involved in) protein stabilization
GO:0050919 (involved in) negative chemotaxis
GO:0051006 (involved in) positive regulation of lipoprotein lipase activity
GO:0051180 (involved in) vitamin transport
GO:0051345 (involved in) positive regulation of hydrolase activity
GO:0051346 (involved in) negative regulation of hydrolase activity
GO:0051496 (involved in) positive regulation of stress fiber assembly
GO:0055091 (involved in) phospholipid homeostasis
GO:0060354 (involved in) negative regulation of cell adhesion molecule production
GO:0060761 (involved in) negative regulation of response to cytokine stimulus
GO:0070328 (involved in) triglyceride homeostasis
GO:0070508 (involved in) cholesterol import
GO:0120009 (involved in) intermembrane lipid transfer
GO:1900026 (involved in) positive regulation of substrate adhesion-dependent cell spreading
GO:1902995 (involved in) positive regulation of phospholipid efflux
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005769 (located in) early endosome
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0030139 (located in) endocytic vesicle
GO:0031410 (located in) cytoplasmic vesicle
GO:0034774 (located in) secretory granule lumen
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0071682 (located in) endocytic vesicle lumen
GO:0072562 (located in) blood microparticle
GO:1903561 (located in) extracellular vesicle
GO:0034361 (part of) very-low-density lipoprotein particle
GO:0034364 (part of) high-density lipoprotein particle
GO:0034366 (part of) spherical high-density lipoprotein particle
GO:0042627 (part of) chylomicron

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)