Click here to access PB0085 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0085 Q9UGM5 Fetuin-B FETUB 16G2, Gugu, IRL685 Homo_sapiens Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.

DomainsGene Ontology
PF00031 (2_Cystatin)
GO:0003674 (enables) molecular_function
GO:0004857 (enables) enzyme inhibitor activity
GO:0004866 (enables) endopeptidase inhibitor activity
GO:0004869 (enables) cysteine-type endopeptidase inhibitor activity
GO:0005515 (enables) protein binding
GO:0008191 (enables) metalloendopeptidase inhibitor activity
GO:0030414 (enables) peptidase inhibitor activity
GO:0007338 (involved in) single fertilization
GO:0007339 (involved in) binding of sperm to zona pellucida
GO:0008150 (involved in) biological_process
GO:0010466 (involved in) negative regulation of peptidase activity
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)