Click here to access PB0084 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0084 P05997 Collagen alpha-2(V) chain COL5A2 EDSC, EDSCL2, collagen type V alpha 2 chain Homo_sapiens Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity).

DomainsGene Ontology
PF00093 (VWC)
PF01391 (5_Collagen)
PF01410 (COLFI)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0030020 (enables) extracellular matrix structural constituent conferring tensile strength
GO:0046332 (enables) SMAD binding
GO:0046872 (enables) metal ion binding
GO:0001501 (involved in) skeletal system development
GO:0001503 (involved in) ossification
GO:0030198 (involved in) extracellular matrix organization
GO:0030199 (involved in) collagen fibril organization
GO:0043588 (involved in) skin development
GO:0048592 (involved in) eye morphogenesis
GO:0071230 (involved in) cellular response to amino acid stimulus
GO:1903225 (involved in) negative regulation of endodermal cell differentiation
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0031012 (located in) extracellular matrix
GO:0005581 (part of) collagen trimer
GO:0005588 (part of) collagen type V trimer
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)