Click here to access PB0080 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0080 P01031 Complement C5 C5 C5D, C5a, C5b, CPAMD4, ECLZB Homo_sapiens C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

DomainsGene Ontology
PF00207 (A2M)
PF01759 (NTR)
PF01821 (ANATO)
PF01835 (MG2)
PF07677 (A2M_recep)
PF07678 (TED_complement)
PF07703 (A2M_BRD)
PF17789 (MG4)
PF17790 (MG1)
PF17791 (MG3)
GO:0004866 (enables) endopeptidase inhibitor activity
GO:0005102 (enables) signaling receptor binding
GO:0005515 (enables) protein binding
GO:0008009 (enables) chemokine activity
GO:0001701 (involved in) in utero embryonic development
GO:0002376 (involved in) immune system process
GO:0006935 (involved in) chemotaxis
GO:0006954 (involved in) inflammatory response
GO:0006956 (involved in) complement activation
GO:0006957 (involved in) complement activation, alternative pathway
GO:0006958 (involved in) complement activation, classical pathway
GO:0007166 (involved in) cell surface receptor signaling pathway
GO:0007186 (involved in) G protein-coupled receptor signaling pathway
GO:0010575 (involved in) positive regulation of vascular endothelial growth factor production
GO:0010760 (involved in) negative regulation of macrophage chemotaxis
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0019835 (involved in) cytolysis
GO:0032722 (involved in) positive regulation of chemokine production
GO:0045087 (involved in) innate immune response
GO:0045766 (involved in) positive regulation of angiogenesis
GO:0060326 (involved in) cell chemotaxis
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0070062 (located in) extracellular exosome
GO:0005579 (part of) membrane attack complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)