Click here to access PB0077 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0077 P04114 Apolipoprotein B-100 APOB FCHL2, FLDB, LDLCQ4, apoB-100, apoB-48, apolipoprotein B Homo_sapiens Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.

DomainsGene Ontology
PF01347 (Vitellogenin_N)
PF06448 (DUF1081)
PF09172 (DUF1943)
PF12491 (ApoB100_C)
GO:0005319 (enables) lipid transporter activity
GO:0005515 (enables) protein binding
GO:0005543 (enables) phospholipid binding
GO:0008201 (enables) heparin binding
GO:0035473 (enables) lipase binding
GO:0050750 (enables) low-density lipoprotein particle receptor binding
GO:0120020 (enables) cholesterol transfer activity
GO:0001701 (involved in) in utero embryonic development
GO:0006629 (involved in) lipid metabolic process
GO:0006642 (involved in) triglyceride mobilization
GO:0006869 (involved in) lipid transport
GO:0007283 (involved in) spermatogenesis
GO:0007399 (involved in) nervous system development
GO:0008202 (involved in) steroid metabolic process
GO:0008203 (involved in) cholesterol metabolic process
GO:0009566 (involved in) fertilization
GO:0009615 (involved in) response to virus
GO:0009743 (involved in) response to carbohydrate
GO:0009791 (involved in) post-embryonic development
GO:0010033 (involved in) response to organic substance
GO:0010269 (involved in) response to selenium ion
GO:0010628 (involved in) positive regulation of gene expression
GO:0010744 (involved in) positive regulation of macrophage derived foam cell differentiation
GO:0010884 (involved in) positive regulation of lipid storage
GO:0010886 (involved in) positive regulation of cholesterol storage
GO:0016042 (involved in) lipid catabolic process
GO:0019433 (involved in) triglyceride catabolic process
GO:0030301 (involved in) cholesterol transport
GO:0030317 (involved in) flagellated sperm motility
GO:0032355 (involved in) response to estradiol
GO:0032496 (involved in) response to lipopolysaccharide
GO:0033344 (involved in) cholesterol efflux
GO:0034374 (involved in) low-density lipoprotein particle remodeling
GO:0034379 (involved in) very-low-density lipoprotein particle assembly
GO:0034383 (involved in) low-density lipoprotein particle clearance
GO:0042157 (involved in) lipoprotein metabolic process
GO:0042158 (involved in) lipoprotein biosynthetic process
GO:0042159 (involved in) lipoprotein catabolic process
GO:0042632 (involved in) cholesterol homeostasis
GO:0042953 (involved in) lipoprotein transport
GO:0045540 (involved in) regulation of cholesterol biosynthetic process
GO:0048844 (involved in) artery morphogenesis
GO:0071356 (involved in) cellular response to tumor necrosis factor
GO:0071379 (involved in) cellular response to prostaglandin stimulus
GO:0120009 (involved in) intermembrane lipid transfer
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005737 (located in) cytoplasm
GO:0005769 (located in) early endosome
GO:0005783 (located in) endoplasmic reticulum
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005789 (located in) endoplasmic reticulum membrane
GO:0005790 (located in) smooth endoplasmic reticulum
GO:0005811 (located in) lipid droplet
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0010008 (located in) endosome membrane
GO:0012506 (located in) vesicle membrane
GO:0030669 (located in) clathrin-coated endocytic vesicle membrane
GO:0031904 (located in) endosome lumen
GO:0031983 (located in) vesicle lumen
GO:0043025 (located in) neuronal cell body
GO:0043202 (located in) lysosomal lumen
GO:0043231 (located in) intracellular membrane-bounded organelle
GO:0070062 (located in) extracellular exosome
GO:0070971 (located in) endoplasmic reticulum exit site
GO:0071682 (located in) endocytic vesicle lumen
GO:0034359 (part of) mature chylomicron
GO:0034360 (part of) chylomicron remnant
GO:0034361 (part of) very-low-density lipoprotein particle
GO:0034362 (part of) low-density lipoprotein particle
GO:0034363 (part of) intermediate-density lipoprotein particle
GO:0034364 (part of) high-density lipoprotein particle
GO:0042627 (part of) chylomicron

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)