Click here to access PB0075 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0075 P14543 Nidogen-1 NID1 NID Homo_sapiens Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.

DomainsGene Ontology
PF00058 (3_Ldl_recept_b)
PF00086 (Thyroglobulin_1)
PF06119 (NIDO)
PF07474 (G2F)
PF07645 (EGF_CA)
PF12662 (cEGF)
PF12947 (2_EGF_3)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005509 (enables) calcium ion binding
GO:0005518 (enables) collagen binding
GO:0043236 (enables) laminin binding
GO:0043237 (enables) laminin-1 binding
GO:0043394 (enables) proteoglycan binding
GO:0050840 (enables) extracellular matrix binding
GO:0007155 (involved in) cell adhesion
GO:0007160 (involved in) cell-matrix adhesion
GO:0010811 (involved in) positive regulation of cell-substrate adhesion
GO:0030198 (involved in) extracellular matrix organization
GO:0032836 (involved in) glomerular basement membrane development
GO:0071711 (involved in) basement membrane organization
GO:0005886 (is active in) plasma membrane
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0031012 (located in) extracellular matrix
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0071944 (located in) cell periphery

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)