Click here to access PB0074 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0074 O60687 Sushi repeat-containing protein SRPX2 SRPX2 BPP, CBPS, PMGX, RESDX, SRPUL Homo_sapiens Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.

DomainsGene Ontology
PF00084 (3_Sushi)
PF02494 (HYR)
PF13778 (DUF4174)
GO:0005102 (enables) signaling receptor binding
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0036458 (enables) hepatocyte growth factor binding
GO:0042802 (enables) identical protein binding
GO:0001525 (involved in) angiogenesis
GO:0007155 (involved in) cell adhesion
GO:0042325 (involved in) regulation of phosphorylation
GO:0048870 (involved in) cell motility
GO:0051965 (involved in) positive regulation of synapse assembly
GO:0071625 (involved in) vocalization behavior
GO:0090050 (involved in) positive regulation of cell migration involved in sprouting angiogenesis
GO:0098609 (involved in) cell-cell adhesion
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005737 (located in) cytoplasm
GO:0009986 (located in) cell surface
GO:0030054 (located in) cell junction
GO:0045202 (located in) synapse
GO:0060076 (located in) excitatory synapse
GO:0097060 (located in) synaptic membrane
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)