Click here to access PB0072 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0072 Q8IUX7 Adipocyte enhancer-binding protein 1 AEBP1 ACLP, AE binding protein 1 Homo_sapiens May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.

DomainsGene Ontology
PF00246 (Peptidase_M14)
PF00754 (F5_F8_type_C)
GO:0000977 (enables) RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001227 (enables) DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003677 (enables) DNA binding
GO:0004180 (enables) carboxypeptidase activity
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005516 (enables) calmodulin binding
GO:0005518 (enables) collagen binding
GO:0008270 (enables) zinc ion binding
GO:0000122 (involved in) negative regulation of transcription by RNA polymerase II
GO:0006355 (involved in) regulation of transcription, DNA-templated
GO:0006508 (involved in) proteolysis
GO:1904026 (involved in) regulation of collagen fibril organization
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm
GO:0070062 (located in) extracellular exosome
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)