Click here to access PB0069 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0069 Q15063 Periostin POSTN OSF-2, OSF2, PDLPOSTN, PN Homo_sapiens Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity).

DomainsGene Ontology
PF02469 (Fasciclin)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0046872 (enables) metal ion binding
GO:0050839 (enables) cell adhesion molecule binding
GO:0007155 (involved in) cell adhesion
GO:0008593 (involved in) regulation of Notch signaling pathway
GO:0009888 (involved in) tissue development
GO:0030198 (involved in) extracellular matrix organization
GO:0071307 (involved in) cellular response to vitamin K
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005794 (located in) Golgi apparatus
GO:0005802 (located in) trans-Golgi network
GO:0031012 (located in) extracellular matrix
GO:0062023 (part of) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)